Protein Synthesis: Translation and Posttranslational Modifications
نویسنده
چکیده
Messenger RNA Is the Carrier of Information Present in DNA 00 Ribosomes Are Workbenches for Protein Biosynthesis 00 Transfer RNA Acts as a Bilingual Translator Molecule 00 The Genetic Code Uses a Four-Letter Alphabet of Nucleotides 00 Codons in mRNA Are Three-Letter Words 00 Punctuation 00 Codon–Anticodon Interactions Permit Reading of mRNA 00 ‘‘Breaking’’ the Genetic Code 00 Mutations 00 Aminoacylation of Transfer RNA Activates Amino Acids for Protein Synthesis 00 Specificity and Fidelity of Aminoacylation Reactions 00
منابع مشابه
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors
Bacterial protein synthesis is intricately connected to metabolic rate. One of the ways in which bacteria respond to environmental stress is through posttranslational modifications of translation factors. Translation elongation factor Tu (EF-Tu) is methylated and phosphorylated in response to nutrient starvation upon entering stationary phase, and its phosphorylation is a crucial step in the pa...
متن کاملPotential Protein Post-translational Modification in Adiponectin
Post-translational modifications of proteins control many biological processes. This is also an important process in the pathogenesis of diabetes mellitus. Adiponectin is an insulin-sensitizing adipokine with antidiabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. The role of posttranslational modifications in regulating the biosynthesis of high molecular weight adipo...
متن کاملPosttranslational Modifications of Myosin Light Chains Determine the Protein Fate
The advances in proteomics over the last decade have made it possible for a more detailed study of protein posttranslational modifications. Posttranslational modification of proteins is an important signaling mechanism regulating vital pathways ranging from transcription to translation, in metabolism, cell survival, and cell death. Posttranslational modification of proteins has commonly been as...
متن کاملInteraction of Mycobacterium tuberculosis elongation factor Tu with GTP is regulated by phosphorylation.
During protein synthesis, translation elongation factor Tu (Ef-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the acceptor site on the ribosome. The activity of Ef-Tu is dependent on its interaction with GTP. Posttranslational modifications, such as phosphorylation, are known to regulate the activity of Ef-Tu in several prokaryotes. Although a study of the Myc...
متن کاملSynthesis, modifications, and turnover of proteins during aging.
Slowing down of bulk protein synthesis is one of the most commonly observed biochemical changes during aging. The implications and consequences of slower rates of protein synthesis are manifold, including a decrease in the availability of enzymes for the maintenance, repair, and normal metabolic functioning of the cell, an inefficient removal of inactive, abnormal, and damaged macromolecules in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 1996